After treatment, changes in motor capacity in CP children do not necessarily predict their performance in daily life

After an intensive treatment period, changes in motor capacity in children with cerebral palsy, as observed in a standardized environment, do not correlate well with actual motor performance in daily life, a new study suggests. The study was published in Child: Care, Health and Development.

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Marisa Wexler MS, Cerebral Palsy News Today December 11, 2019

The ultimate goal of different therapeutic interventions for CP is to improve children’s motor performance — that is, their ability to do activities that require movement in daily life. However, many studies don’t use motor performance as an outcome, instead relying on motor capacity — children’s ability to do things in a controlled environment, e.g. executing tasks in a lab.

Capacity is used instead of performance because it’s easier to measure, and often assumed to be a reasonable proxy for performance, but this assumption isn’t backed up by objective data.

In the new study, researchers put this assumption to the test. They used data from a previous clinical trial, called the SPACE BOP study, in which 65 children with CP (28 female, 37 male, average age of 7 years and 3 months, GMFCS levels I-III) were given 12 weeks of intensive physical therapy aimed at improving motor function.

Some of the children were also treated with botulinum toxin injections — which was what the original trial was investigating — but for the current analysis, all of the children were assessed as one group.

Motor capacity in this new study was measured via three tests: Gross Motor Function Measure GMFM, (generally considered the “gold standard” for measuring motor capacity), functional muscle strength FMS, and walking speed (WS).

Motor performance was assessed by having the children wear an Actigraph-GT3X+ device for at least seven days (minimum eight hours per day) during daily life activities. This device, worn on the wrist like a watch, measures daily activity, not unlike commercial fitness trackers such as Fitbit.

The researchers looked at changes in these measurements by comparing scores measured at the start of the intervention to those measured after 12 and 24 weeks. “It is important to look at change scores at both 12 and 24 weeks because a change in motor performance generally takes time,” the researchers said.

Then, the team constructed statistical models to see how well changes in capacity measurements lined up with those in performance measurements.

At 12 weeks, no statistically significant associations were found between changes in capacity and performance.

At 24 weeks, statistically significant associations were found between functional muscle strength and walking speed measurements and motor performance; children with higher scores in these assessments spent significantly less time being sedentary. Overall, these measurements explained about 16% of the variance in sedentary time.

“We found that changes in motor capacity were mostly not accompanied by changes in motor performance in ambulatory children with CP within the context of one distinct intensive treatment period,” the researchers said.

Because of this, they emphasized a need to re-evaluate treatment interventions that are aimed at improving capacity but not necessarily performance.

The researchers said that incorporating interventions “more specifically focusing on improving motor performance into current treatment programs (based on individual patient goals and needs), creating social and environmental opportunities to optimize the use of motor capacity in daily life and evaluation of normal day to day programs of children with CP probably is a good starting point in reaching long term improvement in both motor capacity and motor performance.”

Marisa Wexler MS
Marisa holds an MS in Cellular and Molecular Pathology from the University of Pittsburgh, where she studied novel genetic drivers of ovarian cancer. She specializes in cancer biology, immunology, and genetics. Marisa began working with BioNews in 2018, and has written about science and health for SelfHacked and the Genetics Society of America. She also writes/composes musicals and coaches the University of Pittsburgh fencing club.
Fact checked by Ana de Barros PhD
Ana holds a PhD in Immunology from the University of Lisbon and worked as a postdoctoral researcher at Instituto de Medicina Molecular (iMM) in Lisbon, Portugal. She graduated with a BSc in Genetics from the University of Newcastle and received a Masters in Biomolecular Archaeology from the University of Manchester, England. After leaving the lab to pursue a career in Science Communication, she served as the Director of Science Communication at iMM.

Source Cerebral Palsy News Today

  References

Relationship between changes in motor capacity and objectively measured motor performance in ambulatory children with spastic cerebral palsy, Halma E, Bussmann JBJ, van den Berg-Emons HJG, Sneekes EM, Pangalila R, Schasfoort FC; SPACE BOP study group. Child Care Health Dev. 2019 Nov 22. doi: 10.1111/cch.12719. [Epub ahead of print]

  Further reading

Relationship between gross motor function and the function, activity and participation components of the International Classification of Functioning in children with spastic cerebral palsy, Lee BH. J Phys Ther Sci. 2017 Oct;29(10):1732-1736. doi: 10.1589/jpts.29.1732. Epub 2017 Oct 21. Full text

Exercise interventions for cerebral palsy, Ryan JM, Cassidy EE, Noorduyn SG, O’Connell NE. Cochrane Database Syst Rev. 2017 Jun 11;6:CD011660. doi: 10.1002/14651858.CD011660.pub2. Review. Full text

Also see
Young CP Adults Report Overall Good Quality of Life, But Problems with Pain, Fatigue and Sleep Persist in Cerebral Palsy News Today

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