Does physical activity impact risk of knee osteoarthritis?

In an analysis published in Arthritis & Rheumatology, investigators did not find any link between the amount and duration of physical activity with individuals’ risk of developing knee osteoarthritis.

Wiley  November 3, 2021

The analysis included six global community-based studies including a total of 5,065 participants with and without knee osteoarthritis who were followed for five to 12 years.

“Knowing that the amount of physical activity and time spent doing it is not associated with the development of knee osteoarthritis is important evidence for both clinicians and the public who may need to consider this when prescribing physical activity for health,” said co–lead author Thomas Perry BSc PhD, of the University of Oxford, in the UK.

Next, it will be important to understand the role of injury and specific types of activity within this association, noted co–lead author Lucy S. Gates PhD, of the University of Southampton, and co–senior author Maria Sanchez-Santos, of the University of Oxford.

About Journal
Arthritis & Rheumatology, an official journal of the American College of Rheumatology, is a peer-reviewed publication for scientists and clinicians interested in the natural history, pathophysiology, treatment, and outcome of the rheumatic diseases. Arthritis & Rheumatology publishes the highest quality basic and clinical research related to the rheumatic diseases, encompassing a wide range of areas of investigative activity. In addition, the journal publishes review articles, editorials, and other educational material intended for both researchers and clinicians. Serving the worldwide community of rheumatology investigators and clinicians, Arthritis & Rheumatology is known internationally as a top rheumatology research journal.
About Wiley
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Source Wiley


Recreational Physical Activity and Risk of Incident Knee Osteoarthritis: an international meta-analysis of individual participant-level data, Gates LS, Perry TA, Golightly YM, Nelson AE, Callahan LF, Felson D, Nevitt M, Jones G, Cooper C, Batt ME, Sanchez-Santos MT, Arden NK. Arthritis Rheumatol. 2021 Nov 3. doi: 10.1002/art.42001. Epub ahead of print. PDF

  Further reading

Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines, Arden NK, Perry TA, Bannuru RR, Bruyère O, Cooper C, Haugen IK, Hochberg MC, McAlindon TE, Mobasheri A, Reginster JY. Nat Rev Rheumatol. 2021 Jan;17(1):59-66. doi: 10.1038/s41584-020-00523-9. Epub 2020 Oct 28. PDF

Association of Long-term Strenuous Physical Activity and Extensive Sitting With Incident Radiographic Knee Osteoarthritis, Chang AH, Lee JJ, Chmiel JS, Almagor O, Song J, Sharma L. JAMA Netw Open. 2020 May 1;3(5):e204049. doi: 10.1001/jamanetworkopen.2020.4049. Full text

Relation of physical activity time to incident disability in community dwelling adults with or at risk of knee arthritis: prospective cohort study, Dunlop DD, Song J, Semanik PA, Sharma L, Bathon JM, Eaton CB, Hochberg MC, Jackson RD, Kwoh CK, Mysiw WJ, Nevitt MC, Chang RW. BMJ. 2014 Apr 29;348:g2472. doi: 10.1136/bmj.g2472. Full text

OARSI guidelines for the non-surgical management of knee osteoarthritis, McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, Hawker GA, Henrotin Y, Hunter DJ, Kawaguchi H, Kwoh K, Lohmander S, Rannou F, Roos EM, Underwood M. Osteoarthritis Cartilage. 2014 Mar;22(3):363-88. doi: 10.1016/j.joca.2014.01.003. Epub 2014 Jan 24. Full text

Exercise and knee osteoarthritis: benefit or hazard? Bosomworth NJ. Can Fam Physician. 2009 Sep;55(9):871-8. Full text

Physical activity at leisure and risk of osteoarthritis, Lane NE. Ann Rheum Dis. 1996 Sep;55(9):682-4. doi: 10.1136/ard.55.9.682. Full text

Also see
Strenuous Physical Activity May Be Beneficial—Not Harmful—for Patients At Risk of Knee Osteoarthritis Docwire News
Strenuous Exercise Is Safe for People at Risk for Knee Osteoarthritis Everyday Health
7 Surprising Things That Can Make Knee Osteoarthritis Pain Worse Everyday Health
Knee OA guidance for clinicians simplified and streamlined University of Oxford

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