Smartphone case offers blood glucose monitoring on the go

Engineers at the University of California San Diego have developed a smartphone case and app that could make it easier for patients to record and track their blood glucose readings, whether they’re at home or on the go.

Liezel Labios, Jacobs School of Engineering, University of California, San Diego December 17, 2018

Currently, checking blood sugar levels can be a hassle for people with diabetes, especially when they have to pack their glucose monitoring kits around with them every time they leave the house.

“Integrating blood glucose sensing into a smartphone would eliminate the need for patients to carry a separate device,” said Patrick Mercier, a professor of electrical and computer engineering at UC San Diego. “An added benefit is the ability to autonomously store, process and send blood glucose readings from the phone to a care provider or cloud service.”

The device, called GlucPhone, is a new proof-of-concept portable glucose sensing system developed by Mercier, nano-engineering professor Joseph Wang, and their colleagues at the UC San Diego Jacobs School of Engineering. Wang and Mercier are the director and co-director, respectively, of the Center for Wearable Sensors at UC San Diego. Their team published the work in Biosensors and Bioelectronics.

GlucPhone has two main parts. One is a slim, 3D printed case that fits over a smartphone and has a permanent, reusable sensor on one corner. The second part consists of small, one-time use, enzyme-packed pellets that magnetically attach to the sensor. The pellets are housed inside a 3D printed stylus attached to the side of the smartphone case.

To run a test, the user would first take the stylus and dispense a pellet onto the sensor—this step activates the sensor. The user would then drop a blood sample on top. The sensor measures the blood glucose concentration, then wirelessly transmits the data via Bluetooth to a custom-designed Android app that displays the numbers on the smartphone screen. The test takes about 20 seconds. Afterwards, the used pellet is discarded, deactivating the sensor until the next test. The stylus holds enough pellets for 30 tests before it needs to be refilled. A printed circuit board enables the whole system to run off a smartphone battery.

The pellets contain an enzyme called glucose oxidase that reacts with glucose. This reaction generates an electrical signal that can be measured by the sensor’s electrodes. The greater the signal, the higher the glucose concentration. The team tested the system on different solutions of known glucose concentrations. The results were accurate throughout multiple tests.

A key innovation in this design is the reusable sensor. In previous glucose sensors developed by the team, the enzymes were permanently built in on top of the electrodes. The problem was that the enzymes wore out after several uses. The sensor would no longer work and had to be completely replaced. Keeping the enzymes in separate pellets resolved this issue.

“This system is versatile and can be easily modified to detect other substances for use in healthcare, environmental and defense applications,” Wang said. The system stores a considerable amount of data so that users can track their readings over long time periods. However, there is a trade-off in price. While the reusable glucose sensor and 3D printed parts are inexpensive, refill pellets may be slightly more costly than test strips in today’s glucose monitoring kits.

The team envisions one day integrating glucose sensing directly into a smartphone rather than a case. The work is currently at the proof-of-concept stage. Some next steps include testing on actual blood samples and minimizing sample volumes—the current prototype uses at least a dozen drops of sample per test, so researchers aim to cut that down to an amount that’s normally extracted from a finger prick. They also plan to include a function in the app that sends phone alerts reminding users to check their blood sugar.

This work was supported in part by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (award no. R21EB019698).

Source University of California, San Diego

Re-usable electrochemical glucose sensors integrated into a smartphone platform, Bandodkar AJ, Imani S, Nuñez-Flores R, Kumar R, Wang C, Mohan AMV, Wang J, Mercier PP. Biosens Bioelectron. 2018 Mar 15;101:181-187. doi: 10.1016/j.bios.2017.10.019. Epub 2017 Oct 13.

A wearable chemical–electrophysiological hybrid biosensing system for real-time health and fitness monitoring, Somayeh Imani, Amay J Bandodkar, A M Vinu Mohan, Rajan Kumar, Shengfei Yu, Joseph Wang & Patrick P Mercier. Nature Communications volume 7, Article number: 11650 (2016) doi: 10.1038/ncomms11650

Biosensors and bioelectronics on smartphone for portable biochemical detection, Zhang D, Liu Q. Biosens Bioelectron. 2016 Jan 15;75:273-84. doi: 10.1016/j.bios.2015.08.037. Epub 2015 Aug 20.

Non-invasive wearable electrochemical sensors: a review, Bandodkar AJ, Wang J. Trends Biotechnol. 2014 Jul;32(7):363-71. doi: 10.1016/j.tibtech.2014.04.005. Epub 2014 May 19.

Also see
Reusable glucose meter paired with smartphone for on-the-go monitoring in National Institutes of Health