Imagining grasping may help restore hand function in spastic CP children

Children with unilateral spastic cerebral palsy (CP) have a preserved ability to imagine grasping with both hands, according to a new study.

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by José Marques Lopes PhD, Cerebral Palsy News Today September 18, 2019

The findings suggest that tapping into that ability during rehabilitation therapy could help recover hand function and upper limb movements in children with CP. The research appeared in the journal Frontiers in Neurology.

Children with unilateral CP, who have one side of their body affected by the movement disorder, have shown impairments in motor imagery (MI) — imagining a motor action without actually moving.

A way to test motor imagery is to evaluate people’s performance in the Parsons’ Hand Laterality Judgment task of implicit MI. Participants have to imagine rotating their own hand to match its  movements with an observed one. However, this task has been deemed to not be the most appropriate one for patients with unilateral CP.

One alternative is mental chronometry, which usually requires participants to perform a simple movement and then to imagine performing it. However, this strategy has not been tested to study grasping in children with unilateral CP.

A team of Italian researchers now used behavioral and neuroimaging methods to address this gap.

A group of 10 children with unilateral CP — 5 boys and 5 girls; ages 9-14 — and another of 12 typically developing children (controls) were asked to perform a mental chronometry task. The task required the children to grasp a small plastic sphere placed at one of three different distances with either hand and place it into a container. Participants had to press a central button, perform the action, then return to the button and press it again to stop the trial. The goal was to complete the task as quickly and accurately as possible.

All CP patients had upper limb motor deficits but no major cognitive impairment.

Following that first task, the children were given a new challenge. This motor imagery task required them to press the central button and imagine performing the same action — but with the they had previously used resting immobile near the button. Again, the children had to press the button to stop the trial.

The children were instructed to feel as if they were actually moving their hand and to have their eyes open to avoid the formation of a visual image.

Ten tasks were performed for each hand, at each of three different distances where the sphere was placed or imagined, for a total of 30 trials per task.

The results showed that children with CP took longer to perform both the actual (executed) actions, and the motor imagery tasks, than the controls. In both groups, increasing the distance from the sphere led to increased task duration.

Children with CP were faster when performing both tasks with the preferred hand than with the non-preferred hand. The data also showed a correlation between executed and imagined movement duration in both groups.

A subset of seven children with CP and 10 controls also underwent functional magnetic resonance imaging (fMRI) to examine brain activation during an explicit motor imagery task. The task consisted of imagining an action similar to the one in the previous mental chronometry task.

A total of 32 videos showing a central object — a sphere, cube or cylinder — and a box were presented in blocks lasting 16 seconds each. The children were instructed to imagine themselves performing the action with the non-preferred hand.

Lesions in the children with CP were characterized in several ways, including by white matter loss. There also were gliosis — reactive glial nerve cells in response to damage — and cystic lesions close to the brain’s lateral ventricles, which are cavities filled with cerebrospinal fluid. Other lesions were characterized by diffuse white matter injury and reduced myelin, which refers to a lack of the insulating layer of nerve fibers.

As for fMRI results in typically developing children, higher scores in mental chronometry tasks were associated with increased activation of the intraparietal sulcus, the superior parietal lobule, and the dorsal premotor cortex. The intraparietal sulcus is involved in sensorimotor functions, while the superior parietal lobule is implicated in spatial orientation, as well as cognitive and motor processes. Meanwhile, the dorsal premotor cortex has a known role in hand and finger control.

In turn, the children with CP showed a similar positive correlation between a higher score in the mental chronometry task and brain activation in the intraparietal sulcus, as well as activation in the contralesional (not affected) dorsal premotor cortex, and the putamen during imagination of grasping movements. The putamen are brain regions implicated in the control of movement and posture. Four of these children showed activation in the affected brain hemisphere.

“This study substantiates the view that explicit [motor imagery] ability for grasping actions could be preserved in [unilateral cerebral palsy] children,” the scientists said. “Brain activations related to explicit [motor imagery] support this view.”

The investigators noted that motor imagery is used for rehabilitation with stroke patients and in Parkinson’s disease.

“Our data suggest that employing explicit [motor imagery] strategies as a training tool could support, in CP rehabilitation, recovery of manipulation function and development of upper limb skilled movements,” they added.

José Marques Lopes PhD
José is a science news writer with a PhD in Neuroscience from Universidade of Porto, in Portugal. He has also studied Biochemistry at Universidade do Porto and was a postdoctoral associate at Weill Cornell Medicine, in New York, and at The University of Western Ontario in London, Ontario, Canada. His work has ranged from the association of central cardiovascular and pain control to the neurobiological basis of hypertension, and the molecular pathways driving Alzheimer’s disease.

Source Cerebral Palsy News Today


Explicit Motor Imagery for Grasping Actions in Children With Spastic Unilateral Cerebral Palsy, Errante A, Bozzetti F, Sghedoni S, Bressi B, Costi S, Crisi G, Ferrari A, Fogassi L. Front Neurol. 2019 Aug 7;10:837. doi: 10.3389/fneur.2019.00837. eCollection 2019. Full text

  Further reading

Mental chronometry in the pocket? Timing accuracy of web applications on touchscreen and keyboard devices, Pronk T, Wiers RW, Molenkamp B, & Murre J. (2019). Behavior research methods, 10.3758/s13428-019-01321-2. Advance online publication. Full text

Mirror Neuron System Activation in Children With Unilateral Cerebral Palsy During Observation of Actions Performed by a Pathological Model, Errante A, Di Cesare G, Pinardi C, Fasano F, Sghedoni S, Costi S, Ferrari A, Fogassi L. Neurorehabil Neural Repair. 2019 Jun;33(6):419-431. doi: 10.1177/1545968319847964. Epub 2019 May

Action affordances and visuo-spatial complexity in motor imagery: An fMRI study, Schulz L, Ischebeck A, Wriessnegger SC, Steyrl D, Müller-Putz GR. Brain Cogn. 2018 Jul;124:37-46. doi: 10.1016/j.bandc.2018.03.012. Epub 2018 May 1.

Motor imagery difficulties in children with Cerebral Palsy: A specific or general deficit? Lust JM, Wilson PH, Steenbergen B. Res Dev Disabil. 2016 Oct;57:102-11. doi: 10.1016/j.ridd.2016.06.010. Epub 2016 Jul 9.

Assessment of the structural brain network reveals altered connectivity in children with unilateral cerebral palsy due to periventricular white matter lesions, Pannek K, Boyd RN, Fiori S, Guzzetta A, Rose SE. Neuroimage Clin. 2014 Jun 4;5:84-92. doi: 10.1016/j.nicl.2014.05.018. eCollection 2014. Full text

Effect of motor imagery in children with unilateral cerebral palsy: fMRI study, Chinier E, N’Guyen S, Lignon G, Ter Minassian A, Richard I, Dinomais M. PLoS One. 2014 Apr 9;9(4):e93378. doi: 10.1371/journal.pone.0093378. eCollection 2014. Full text

Assessment of motor imagery in cerebral palsy via mental chronometry: the case of walking, Spruijt S, Jouen F, Molina M, Kudlinski C, Guilbert J, Steenbergen B. Res Dev Disabil. 2013 Nov;34(11):4154-60. doi: 10.1016/j.ridd.2013.08.044. Epub 2013 Sep 26.

Mental rotation task of hands: differential influence number of rotational axes, ter Horst AC, van Lier R, Steenbergen B. Exp Brain Res. 2010 Jun;203(2):347-54. doi: 10.1007/s00221-010-2235-1. Epub 2010 Apr 8. Full text

Motor imagery training in hemiplegic cerebral palsy: a potentially useful therapeutic tool for rehabilitation, Steenbergen B, Crajé C, Nilsen DM, Gordon AM. Dev Med Child Neurol. 2009 Sep;51(9):690-6. doi: 10.1111/j.1469-8749.2009.03371.x. Review. Full text

Dissociating the role of ventral and dorsal premotor cortex in precision grasping, Davare M, Andres M, Cosnard G, Thonnard JL, Olivier E. J Neurosci. 2006 Feb 22;26(8):2260-8. Full text

Graded Motor Imagery posters. Graded Motor Imagery (GMI) exercises your brain and its trillions of connections. Neuro Orthopaedic Institute, Adelaide, Australia

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