Researchers discover way to switch on and speed up tendon healing

Team at National University of Ireland Galway create implantable stimulator device which combines with body power to treat disease, damage and sports injury.

This implantable device acts as mechanical support for damaged tendons and mimics the bioelectrical cues usually provided by collagen during wound healing. Magnus Biggs, Marc Fernández Yagüe. Advanced Science News

Sheila Gorham, National University of Ireland Galway 31 August 2021

Researchers at CÚRAM, the SFI Research Centre for Medical Devices based at NUI Galway, have shown how the simple act of walking can power an implantable stimulator device to speed up treatment of musculoskeletal diseases.

The results have been published in the prestigious journal Advanced Materials.

The research establishes the engineering foundations for a new range of stimulator devices that enable control of musculoskeletal tissue regeneration to treat tendon damage and disease and sports injuries, without the use of drugs or external stimulation.

Lead researcher on the study, CÚRAM Investigator Dr Manus Biggs, said: “One of the most exciting parts of our study is that these implantable devices may be tailored to individual patients or disorders and may show promise in accelerating the repair of sport-related tendon injuries, particularly in athletes.”

The study investigated whether electrical therapy, coupled with exercise, would show promise in treating tendon disease or ruptures. It showed that tendon cell function and repair can be controlled through electrical stimulation from an implantable device which is powered by body movement.

Dr Marc Fernández, who carried out the principal research of the study at CÚRAM, said: “Successful treatment of tendon damage and disease represents a critical medical challenge.

“Our discovery shows that an electrical charge is produced in the treatment target area — the damaged or injured tendon — when the implanted device is stretched during walking. The potential gamechanger here is like a power switch in a cell – the electrical stimulus turns on tendon-specific regenerative processes in the damaged tendon.”

The stimulator device uses a fabric like mesh – known as a piezoelectric material – that produces electricity when stretched or put under mechanical pressure. It is made using a scaffold of nano-fibres which are one-thousandth of the thickness of a human hair

Dr Fernandez added: “We presented an implantable, electrically active device capable of controlling tendon regeneration and healing. Importantly, our research improved the therapeutic performance of the device by enhancing its structure, piezoelectric characteristics, and biological compatibility.

“We also evaluated the individual influence of mechanical, structural, and electrical cues on tendon cell function and were able to show that bioelectric cues contribute significantly in promoting tendon repair.”

Dr Biggs added: “This unique strategy of combining a device which is powered through body-movement and which can induce accelerated tendon healing is expected to significantly impact the field of regenerative devices, specifically in the area of sports or trauma associated injuries.

“These devices are cost-effective, relatively easy to implant and may pave the way for a whole new class of regenerative electrical therapies.”

The research was funded by Science Foundation Ireland and in particular the SFI-BBSRC Partnership programme.
CÚRAM’s research focuses on developing diagnostic devices, biomedical implants, cell-device and drug-device combination products to address unmet clinical needs.
The recent announcement of a €46million reinvestment in CÚRAM by Science Foundation Ireland in February 2021, demonstrates the Government’s strong commitment to the MedTech industry in Ireland, supporting the continuation of substantial academic, industry and clinical collaborations that are central to CÚRAM’s work.

Source National University of Ireland Galway via EurekAlert! AAAS

  References

A Self-Powered Piezo-Bioelectric Device Regulates Tendon Repair-Associated Signaling Pathways through Modulation of Mechanosensitive Ion Channels, Fernandez-Yague MA, Trotier A, Demir S, Abbah SA, Larrañaga A, Thirumaran A, Stapleton A, Tofail SAM, Palma M, Kilcoyne M, Pandit A, Biggs MJ. Adv Mater. 2021 Aug 23:e2008788. doi: 10.1002/adma.202008788. Epub ahead of print. Full text

  Further reading

Remote triggering of TGF-β/Smad2/3 signaling in human adipose stem cells laden on magnetic scaffolds synergistically promotes tenogenic commitment, Matos AM, Gonçalves AI, Rodrigues MT, Miranda MS, Haj AJE, Reis RL, Gomes ME. Acta Biomater. 2020 Sep 1;113:488-500. doi: 10.1016/j.actbio.2020.07.009. Epub 2020 Jul 8.

Also see
Growing new cartilage with magnetic fields and hydrogels Advanced Science News

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