Non-invasive spinal modulation for Cerebral palsy

SpineX, a medtech company based in California, has developed the Spinal Cord Innovation in Pediatrics (SCiP) device, a non-invasive spinal cord neuromodulation technology that is intended to treat children with cerebral palsy.

Conn Hastings, Medgadget November 15, 2022

The technology is designed to be used in conjunction with activity-based neurorehabilitation therapy with the goal of improving functional movements in such children. Through transcutaneous spinal cord neuro-stimulation, the technology aims to modulate dysfunctional brain and spinal cord connectivity. In a recent pilot study, the company reports that 16 pediatric patient volunteers, with a range of cerebral palsy severities and ages, demonstrated improved sensorimotor function after treatment with the device.

Cerebral palsy is a group of movement disorders that typically occur because of damage to the developing brain, with symptoms affecting posture, gait, and balance. At present, there are no therapies to effectively treat cerebral palsy. Some patients undergo invasive surgery in an attempt to address certain symptoms, such as spasticity, but there is a clear need for new effective treatments and less invasive alternatives.

This latest technology may provide a window into the cerebral palsy treatments of the future. The SCiP device is a non-invasive transcutaneous spinal cord neuro-stimulation technology. Designed to be used during physical rehab sessions, the technology aims to improve connectivity between the brain and spinal cord for enhanced rehab.

The company recently published the results of a pilot study in which the device was tested in a group of 16 pediatric cerebral palsy patients. The children received two interventions a week during the study. This involved an activity-based neurorehabilitation therapy sessions, during which the children received neuromodulation treatments from the device. At the end of the 8-week study, the researchers reported that all the treated children demonstrated improved sensorimotor function.

“At just three years old and highly affected by cerebral palsy, our son has shown such exciting progress since he began using SCiP,” said Dana, the mother of one of the participants in the study. “We’re so grateful that our son was included in the clinical study with SCiP as it has opened up a world of possibilities for our son, and we hope others will be able to witness it soon.”

See a video about the exciting study below:

New non-invasive spinal neuromodulation device offers hope for children with cerebral palsy. SpineX Inc. Youtube Oct 5, 2022
Conn Hastings
Conn Hastings received a PhD from the Royal College of Surgeons in Ireland for his work in drug delivery, investigating the potential of injectable hydrogels to deliver cells, drugs and nanoparticles in the treatment of cancer and cardiovascular diseases. After achieving his PhD and completing a year of postdoctoral research, Conn pursued a career in academic publishing, before becoming a full-time science writer and editor, combining his experience within the biomedical sciences with his passion for written communication.

Source Medgadget

  References

A pilot study combining noninvasive spinal neuromodulation and activity-based neurorehabilitation therapy in children with cerebral palsy, Hastings S, Zhong H, Feinstein R, Zelczer G, Mitrovich C, Gad P, Edgerton VR. Nat Commun. 2022 Oct 5;13(1):5660. doi: 10.1038/s41467-022-33208-w. Full text, PDF

  Further reading

Mechanically assisted walking training for walking, participation, and quality of life in children with cerebral palsy, Chiu HC, Ada L, Bania TA. Cochrane Database Syst Rev. 2020 Nov 18;11(11):CD013114. doi: 10.1002/14651858.CD013114.pub2. Full text, PDF

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