Insoles or braces show best pain relief for knee OA

The use of braces or insoles in combination with non-biomechanical treatments appear to deliver the greatest pain relief for patients with medial tibiofemoral osteoarthritis, although the evidence supporting these interventions has a high degree of uncertainty, according findings from a large meta-analysis of randomized, controlled trials presented at the Osteoarthritis Research Society International OARSI 2021 World Congress.

Evoke 3D printed custom knee brace. Osskin

Bianca Nogrady, Medscape May 14, 2021

“It’s been highlighted for several years now that due to the high rate of joint replacement, we need to promote more effective nonsurgical treatments,” Ans van Ginckel, of Ghent (Belgium) University, told the conference.

However, guidelines on the use of biomechanical treatments for knee OA pain vary widely, and there are few studies that compare the effectiveness of different interventions.

To address this, van Ginckel and colleagues conducted a network meta-analysis of 27 randomized, controlled trials – involving a total of 2,413 participants – of biomechanical treatments for knee OA pain. The treatments included were valgus braces, combined brace treatment (with added nonbiomechanical treatment), lateral or medial wedged insoles, combined insole treatment (with added nonbiomechanical treatment), contralateral cane use, gait retraining, and modified shoes.

“These treatments are mainly based on the premise that people with knee osteoarthritis likely experience a higher external knee adduction moment during walking, compared to healthy people,” van Ginckel told the conference, which is sponsored by the Osteoarthritis Research Society International. “This has been associated to some extent with disease onset, severity, and progression.”

When compared to nonbiomechanical controls, walking sticks and canes were the only intervention that showed a benefit in reducing pain, although the authors described the data supporting this as “high risk.”

When all the treatments were ranked according to the degree of pain relief seen in studies, combined insole and/or combined brace treatments showed the greatest degree of benefit.

However, van Ginckel said the evidence supporting even these treatments was of low to very low certainty, there was significant variation in the control treatments used in the studies, and the confidence intervals were wide. This also reflected the multifactorial nature of pain in knee OA, she said.

“A plausible explanation is the partial role in the biomechanics of the pathogenesis of pain and the multifactorial nature of pain,” she said.

Commenting on the study, Rik Lories MD PhD, head of the division of rheumatology at University Hospitals Leuven (Belgium) and of the department of development and regeneration at Catholic University Leuven, said the findings of the analysis show how difficult it is to study biomechanical interventions for knee OA.

“It was a smart approach to try to get some more information about a wide array of studies that have been performed, being selective with regards to what to include,” Lories said. “It’s still a big challenge in terms of how do you control for confounders.”

Lories said that he took a positive view of the findings, suggesting that these interventions are unlikely to cause harm, and are therefore “not a road to avoid” in helping to reduce knee OA pain. But he also argued that the analysis pointed to a clear need for better studies of biomechanical interventions for knee OA. “I think that’s an important message that somehow the field has to improve the quality of their trials,” he said in an interview, although he acknowledged that such trials may be difficult to run and get funding for

Van Ginckel was supported by an EU Horizon 2020 fellowship, and a coauthor was supported by the Australian National Health and Medical Research Council. No conflicts of interest were declared.
This article originally appeared on, part of the Medscape Professional Network.

Source Medscape


Comparative efficacy of biomechanical treatments on knee osteoarthritis pain: a network meta-analysis of randomized controlled trials, A. Van Ginckel, M. Hall, R. De Ridder. Osteoarthritis and Cartilage, Volume 29, Supplement 1, 2021, Pages S79-S80, ISSN 1063-4584,

  Further reading

Comparative efficacy of treatments for patients with knee osteoarthritis: a network meta-analysis, Li B, Zhang Y, Bi L. Eur J Med Res. 2020 Jul 20;25(1):27. doi: 10.1186/s40001-020-00426-1. Full text

The effect of a knee brace in dynamic motion-An instrumented gait analysis, Siebers HL, Eschweiler J, Pinz J, Tingart M, Rath B. PLoS One. 2020 Sep 10;15(9):e0238722. doi: 10.1371/journal.pone.0238722. Full text

Braces and orthoses for treating osteoarthritis of the knee, Duivenvoorden T, Brouwer RW, van Raaij TM, Verhagen AP, Verhaar JA, Bierma-Zeinstra SM. Cochrane Database Syst Rev. 2015 Mar 16;2015(3):CD004020. doi: 10.1002/14651858.CD004020.pub3. Full text

Braces and orthoses for treating osteoarthritis of the knee, Brouwer RW, Jakma TS, Verhagen AP, Verhaar JA, Bierma-Zeinstra SM. Cochrane Database Syst Rev. 2005 Jan 25;(1):CD004020. doi: 10.1002/14651858.CD004020.pub2. Update in: Cochrane Database Syst Rev. 2015;3:CD004020.

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