Molecular biology

New therapeutic approach for osteoarthritis discovered

Osteoarthritis was long considered to be the result of wear and tear in advanced age. In the meantime, more and more studies are linking the degradation of articular cartilage to inflammatory and metabolic processes in the joint. … READ MORE

Skeletal muscles and satellite cells: How exercise leads to longer lives

A trio of researchers at Ottawa Hospital Research Institute has conducted a review of the ways that periodic activation of satellite cells through exercise can lessen senescence acquisition and myogenic decline. Satellite cell … READ MORE

FDA approves new drug to treat common form of muscular dystrophy based on research from U of A scientist

Created using synthetic DNA, viltolarsen is an excellent example of precision medicine. The U.S. FDA has approved a drug called viltolarsen to treat Duchenne muscular dystrophy. The drug was developed based on research by U of A … READ MORE

Altered composition, structure of muscles linked to stiffness, movement limits in CP children

Muscle composition and structure is altered in children with cerebral palsy — with greater amounts of collagen in the muscles’ network of proteins and sugars — making these patients more prone to stiffness and contractures that … READ MORE

How do muscle and tendon connections last a lifetime?

Cell biologists show in fruit flies how a protein controls mechanical stress on muscle-tendon attachments. Lengthwise cut through the thorax of a fruit fly having an inserted force sensor in the talin protein. The force sensor on the … READ MORE

Exercise helps prevent cartilage damage caused by arthritis

Exercise helps to prevent the degradation of cartilage caused by osteoarthritis, according to a new study from Queen Mary University of London. Medical Xpress. CC0 Public Domain Rupert Marquand, Queen Mary University of London 27 … READ MORE

New clues to the origin and progression of multiple sclerosis

Mapping of a certain group of cells, known as oligodendrocytes, in the central nervous system of a mouse model of multiple sclerosis (MS), shows that they might have a significant role in the development of the disease. The discovery … READ MORE

Scientists uncover why knee joint injury leads to osteoarthritis

Knee joint injuries are typically related to sports, such as football, rugby or ice hockey, but people often do not know that such injuries may lead to joint inflammation and post-traumatic osteoarthritis. OssKin Evoke University of … READ MORE

UCalgary scientists discover a new way to battle multiple sclerosis

Findings challenge conventional thinking about the root cause of MS. The Dr. Peter Stys lab within the Hotchkiss Brain Institute at the Cumming School of Medicine, University of Calgary, is equipped with highly specialized microscopes … READ MORE

Breakthrough for SF State kinesiologists studying metabolic protein

New technique could help improve treatment for diabetes and obesity. Assistant Professor of Kinesiology Jimmy Bagley and Irene Tobias, a postdoctoral researcher at CSU Fullerton, analyze muscle fibers. Andy Galpin CSU Fullerton By … READ MORE

Bloodless revolution in diabetes monitoring

Scientists have created a non-invasive, adhesive patch, which promises the measurement of glucose levels through the skin without a finger-prick blood test. The device can measure glucose levels without piercing the skin. University … READ MORE

Surprise finding could lead to new MS treatments

A discovery is providing hope of a new therapeutic target in Multiple Sclerosis (MS) patients that could one day be used to prevent the symptoms and progression of the disease. By removing a protein called calnexin in mice, … READ MORE

Scientists zero in on treatment for Charcot-Marie-Tooth disease

About 1 in 2,500 people have a degenerative nerve disease called Charcot-Marie-Tooth (CMT). The disease is typically diagnosed in children, who can lose their ability to walk and use their hands for fine motor skills. There is no … READ MORE

Researchers watch the knee degenerate and understand how osteoarthritis may begin

Kinesiology study shows how knee cartilage is protected by the menisci. University of Calgary researchers Ziad Abusara and Walter Herzog have discovered that most patients who had their meniscus removed developed knee osteoarthritis. … READ MORE

Osteoarthritis in the XXIst century: Risk factors and behaviours that influence onset and progression

Paddling with Evoke™ brace Musumeci G, Aiello FC, Szychlinska MA, Di Rosa M, Castrogiovanni P, Mobasheri A. International Journal of Molecular Sciences, 2015 Mar 16 Abstract Osteoarthritis (OA) is a growing public health … READ MORE

Keep moving to prevent osteoarthritis, say physicists

Osteoarthritis in the knee is a painful condition affecting nearly half of all Americans at some time – and two thirds of obese adults. Research suggesting that physical activity could help prevent it has been presented this … READ MORE